Cell signaling
System of communication
Follow Cell signaling on Notably News to receive short updates to your email — rarely!
We include updates on Ketamine, Methamphetamine, Methylphenidate, Bupropion, Cocaine, Sertraline, Amitriptyline, Phencyclidine, Fluoxetine, Escitalopram, N,N-Dimethyltryptamine, Venlafaxine, Promethazine, Dextromethorphan, Selective serotonin reuptake inhibitor, Citalopram ... and more.
| 2025 |
Ketamine
The UK Home Office requested a review of ketamine's drug classification, considering changing it to Class A due to increased recreational use and negative health consequences.
|
| 2024 |
Selective serotonin reuptake inhibitor
A systematic review was conducted confirming the effectiveness of SSRIs in reducing symptoms of obsessive-compulsive disorder (OCD) in pediatric populations, particularly when combined with behavioral therapies like exposure and response prevention (ERP).
|
| March 20 2024 |
Selective serotonin reuptake inhibitor
Public Citizen filed a lawsuit against the United States Food and Drug Administration (FDA) on behalf of Dr. Antonei Csoka, seeking to mandate labeling about serious sexual side effects that persist after discontinuing SSRIs and SNRIs.
|
| 2023 |
N,N-Dimethyltryptamine
A scientific study was conducted investigating a novel DMT administration method using a bolus injection combined with a constant-rate infusion, aiming to extend the duration of DMT experiences.
|
| 2023 |
Selective serotonin reuptake inhibitor
A research study identified a possible connection between SSRI usage and the onset of mitral valve regurgitation, suggesting SSRIs might accelerate degenerative mitral valve regurgitation (DMR), particularly in individuals with the 5-HTTLPR genotype.
|
| October 2023 |
Ketamine
Actor Matthew Perry's death was revealed to be caused by a ketamine overdose, highlighting the potentially fatal risks of recreational ketamine use.
|
| 2022 |
Selective serotonin reuptake inhibitor
Diagnostic criteria for Post-SSRI Sexual Dysfunction (PSSD) were proposed, though no agreement on standard diagnosis was reached.
|
| October 2022 |
Roluperidone
The FDA sent Minerva a refusal to file letter regarding the New Drug Application for roluperidone for treating negative symptoms in schizophrenia patients.
|
| August 2022 |
Roluperidone
Minerva Neurosciences submitted a New Drug Application (NDA) to the FDA for roluperidone to treat schizophrenia, following a successful phase III clinical trial published earlier that year.
|
| February 2022 |
Ketamine
The US Food and Drug Administration issued an alert to healthcare professionals about compounded nasal spray products containing ketamine for depression treatment.
|
| 2021 |
Selective serotonin reuptake inhibitor
Swedish study using a within-individual design found that young people most commonly attempt suicide before starting SSRI prescription.
|
| 2021 |
Selective serotonin reuptake inhibitor
A meta-analysis of randomized controlled clinical trials was conducted to evaluate the use of SSRIs in stroke recovery, concluding that there was no evidence supporting their routine use for promoting stroke recovery.
|
| 2021 |
Selective serotonin reuptake inhibitor
Cochrane review concluded SSRIs may only marginally reduce depression symptoms in children and adolescents, with significant methodological limitations noted.
|
| 2021 | CDC reported an increase to 32,537 deaths in the United States involving psychostimulants with abuse potential, primarily methamphetamine. |
| 2020 |
N,N-Dimethyltryptamine
An in-situ hybridization study found mRNA coding for INMT expressed in the human cerebral cortex, choroid plexus, and pineal gland, providing more accurate localization of INMT than previous northern blot analyses.
|
| 2020 | CDC reported 23,837 deaths in the United States involving psychostimulants with abuse potential, primarily methamphetamine. |
| September 2020 |
N,N-Dimethyltryptamine
An in vitro and in vivo study discovered that DMT present in ayahuasca promotes neurogenesis, demonstrating its potential for generating new neurons.
|
| May 2020 |
Roluperidone
Minerva Neurosciences experienced a significant stock market decline of 67% after a clinical trial for roluperidone failed to meet its primary endpoint of reducing negative symptoms of schizophrenia.
|
| 2019 |
N,N-Dimethyltryptamine
Experiments showed that the rat brain is capable of synthesizing and releasing DMT, raising the possibility of a similar phenomenon in human brains.
|
| 2019 |
N,N-Dimethyltryptamine
A large-scale study explored potential links between DMT, other psychedelic substances, and near-death experiences, examining semantic similarities in narratives.
|
| 2019 |
Selective serotonin reuptake inhibitor
The Pharmacovigilance Risk Assessment Committee of the European Medicines Agency (EMA) recommended that packaging leaflets of selected SSRIs and SNRIs should be amended to include information regarding a possible risk of persistent sexual dysfunction.
|
| 2019 |
Ketamine
Esketamine was approved as a nasal spray for treatment-resistant depression by the European Medicines Agency and in the United States.
|
| 2019 |
Ketamine
A large-scale study was conducted examining the similarity between ketamine-induced experiences and near-death experiences (NDEs), finding a high degree of correspondence in written reports compared to other drug experiences.
|
| 2019 | Sam Gor syndicate was responsible for a massive surge of crystal methamphetamine production in the Golden Triangle, specifically Shan State, Myanmar, controlling an estimated 40% of the Asia-Pacific methamphetamine market. |
| 2019 | A systematic review and meta-analysis assessed the efficacy of 17 different pharmacotherapies for amphetamine and methamphetamine addiction. The study found only low-strength evidence that methylphenidate might reduce self-administration, and low to moderate-strength evidence of no benefit for most other medications tested. |
| 2018 |
N,N-Dimethyltryptamine
Electronic cigarette cartridges and vape pens containing DMT began to be sold on the black market, introducing a new method of consuming the substance.
|
| 2018 |
N,N-Dimethyltryptamine
The Swedish Supreme Court concluded that possession of processed plant material containing a significant amount of DMT is illegal, while unprocessed plant material remains legal.
|
| 2018 |
N,N-Dimethyltryptamine
A study was published finding significant relationships between DMT experiences and near-death experiences.
|
| 2018 |
Selective serotonin reuptake inhibitor
Systematic review and network meta-analysis identified escitalopram as one of the most effective antidepressants, comparing 21 antidepressant drugs.
|
| 2018 |
Ketamine
Consensus guidelines on chronic pain were published, evaluating ketamine's efficacy in treating various pain conditions. The guidelines found weak to moderate evidence supporting ketamine's use, with the strongest evidence being for Complex Regional Pain Syndrome (CRPS).
|
| 2018 | A systematic review and network meta-analysis of 50 trials was conducted, examining 12 different psychosocial interventions for amphetamine, methamphetamine, and cocaine addiction. The analysis found that combination therapy using contingency management and community reinforcement approach demonstrated the highest efficacy for abstinence and lowest dropout rates. |
| 2017 |
Selective serotonin reuptake inhibitor
Systematic review suggested that SSRIs' harmful effects may outweigh potential small beneficial effects, which was subsequently criticized by Fredrik Hieronymus et al.
|
| 2016 |
Selective serotonin reuptake inhibitor
Review criticized the FDA Black Box suicide warning, suggesting it might have unintended consequences on suicide rates.
|
| 2015 | A comprehensive review summarized studies on chronic methamphetamine use in rodents, highlighting epigenetic alterations in brain reward pathways and their impact on gene expression associated with addiction. |
| October 2015 |
Ketamine
Australia listed ketamine as a Schedule 8 controlled drug under the Poisons Standard.
|
| 2014 |
N,N-Dimethyltryptamine
In the Republic of Ireland, a member of the Santo Daime church attempted to gain a religious exemption to import DMT, but the attempt failed.
|
| 2014 |
N,N-Dimethyltryptamine
A study reported the biosynthesis of DMT in the human melanoma cell line SK-Mel-147, detailing its metabolism by peroxidases.
|
| 2014 |
N,N-Dimethyltryptamine
Researchers demonstrated the immunomodulatory potential of DMT and 5-MeO-DMT through the Sigma-1 receptor of human immune cells, suggesting potential anti-inflammatory effects and tissue regeneration.
|
| 2014 |
Selective serotonin reuptake inhibitor
Cochrane review found that suicidal ideation remained higher in children treated with antidepressants compared to those treated with psychological therapy at six to nine months.
|
| 2014 | A crucial role was discovered for epigenetic mechanisms in driving lasting changes in gene expression in the brain related to methamphetamine addiction. |
| February 12 2014 |
Ketamine
The United Kingdom labeled ketamine as a Class B drug, increasing legal restrictions on its possession and distribution.
|
| 2013 |
N,N-Dimethyltryptamine
Researchers reported the presence of DMT in the pineal gland microdialysate of rodents, providing evidence of endogenous DMT in the mammalian brain.
|
| 2013 | A study of bioreactors in wastewater found that methamphetamine can be largely degraded within 30 days when exposed to light. |
| December 2013 |
Ketamine
India added ketamine to Schedule X of the Drug and Cosmetics Act, requiring special licensing and strict sales record-keeping to combat recreational use and its potential as a date rape drug.
|
| 2012 |
Selective serotonin reuptake inhibitor
Meta-analysis of fluoxetine and venlafaxine concluded statistically and clinically significant treatment effects relative to placebo across depression severity levels.
|
| 2012 |
Ketamine
A Cochrane review examined ketamine's potential use in treating children with severe acute asthma, finding minimal adverse effects but no significant therapeutic benefit from the limited studies available.
|
| 2011 |
N,N-Dimethyltryptamine
Immunohistochemistry research revealed the presence of INMT in primate nervous tissue, including retina, spinal cord motor neurons, and pineal gland.
|
| 2011 |
Ketamine
A clinical practice guideline was published supporting the use of ketamine as a sedative in emergency medicine, including during physically painful procedures.
|
| 2011 | A scientific study investigated the destruction of methamphetamine using bleach, demonstrating that the effectiveness of degradation correlates with exposure time and concentration. |
|
We are only showing the most recent entries for this topic. |
|
This contents of the box above is based on material from the Wikipedia articles N,N-Dimethyltryptamine, Roluperidone, Ketamine, Selective serotonin reuptake inhibitor, SPIKE (database) & Methamphetamine, which are released under the Creative Commons Attribution-ShareAlike 4.0 International License.